Pharmacometrician Bracknell Berkshire
Salary: £ to £
Help us transform patients’ lives.At UCB, we put our heart, soul, and skills into making a difference for people living with severe disease. Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in our pioneering adventure?
Role OverviewIn this key role he/she will serve as the Advanced Modelling and Simulation(M&S)/Pharmacometrics Expert. Working within a matrix team supporting early (From candidate selection pre-POC) and late phase (post-POC) projects to deliver and apply quantitative solutions to drive the delivery of the translational and clinical development plan.
Working mainly outside the classical clinical/project team frame-work, dealing directly with key individuals (Quantitative Clinical Pharmacologist, Exploratory Statistician, Biomarkers and Therapeutic Experts) to scope the key question/concept, plan a solution, and lead its execution and delivery, providing an answer.
In particular, he/she will provide specialized pharmacometric expertise to multiple projects, and will work within a dedicated team along with an external network of experts to support the delivery of analyses, enhance project impact, develop and apply new methodologies and solutions, whilst remaining at the cutting edge in terms of expertise.
The role can be based in Sough, UK or Belgium
Primary ResponsibilitiesAccountable for scoping and delivering the modelling pharmacometric strategy for assigned projectsDeveloping disease-based PK-PD models and model based meta-analyses to support translation, risk assessment through various decision points (FIH, POC to PH3) in the key (Immunology, Neuroscience, Bone) UCB’s therapeutic areasProviding analyses to support the recommendations for clinical doses and dosing algorithms to the clinical and Development teams and in regulatory documentation.Provide guidance to the quantitative pharmacologist on optimal PK and PK-PD sampling for implementation in the various stages of development, and subsequently perform the population PK and PK-PD analyses (safety and efficacy) on a continuous and live basis as the project progresses.Evaluate the potential use of different technologies and approaches to support project progression e.g. empirical approach, systems pharmacology, sparse methodologyAccountable and responsible for key technical reports (e.g. population PK, PK-PD, trial simulations as well as sections of regulatory documents).Accountable for providing advanced mechanistic modelling support for evaluation of key assets, prior to candidate selectionInitiating and managing collaborations with external experts.
Technical CapabilitiesFunctional scientific skills, including;Physiological and biochemical understanding.Therapeutic Expertise.Experience in pharmacokinetics/pharmacodynamic modelling.Non Linear Mixed Effects Modelling.Knowledge of drug development and the application of modelling in the regulatory and decision making setting.Proficiency in performing data analysis and interpretation with several pieces of software such as;NONMEN and add-ons (PsN, XPose, Pirana, Navigator….)RPhoenixBerkeley MadonnaMATLABEssential RequirementsEducated to Pharm D or PhD (or equivalent) with demonstrated experience (with examples of impact) in the conduct and application of M&S, preferably in the pharmaceutical industry, consultancy group or academic setting. This experience can be validated via publication.Effective oral and written communication skills both within the expert domain and effective with non-experts.Able to communicate complex modelling concepts and results effectively to other functions and project teams.Strong leadership skills.Efficient time management and organization skills.Ability to work in a matrix team.Ability to produce and present quality scientific papers at external meetings and for publication.
About us.UCB- Inspired by Patients. Driven by Science. Everything we do starts with a simple question: “How will this create value for people living with severe diseases?” By putting patients at the heart of what we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.With a team of approximately 7,500 employees and operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases.Curious to know more? Please visit our website www.ucb.com.UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer.
Pharmacometrician Bracknell Berkshire